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http://www.med.umich.edu/opm/newspage/2003/yoyodiet.htm

excerpts:

"Those who gain and/or lose at least 10 pounds in a yearlong period at least five times over a lifetime may be setting themselves up for heart problems after menopause.

"[E]ven if a woman in our study was now thin, getting there by yo-yo dieting was shown to have a negative affect on the blood flow to her heart," says Duvernoy, who is director of the Cardiac Catheterization Laboratory at the VA/Ann Arbor Healthcare System and an assistant professor of internal medicine/cardiology at the U-M Medical School. "This is important because reduced blood flow to the heart could be an indication of a blockage in coronary arteries, or in the small blood vessels of the heart, which could eventually trigger a heart attack or stroke."

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